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Cervical Biopsy

A cervical biopsy is a medical procedure where a small sample of tissue is taken from the cervix, which is the lower part of the uterus. This is done to check for abnormal or precancerous cells that may indicate cervical cancer or other conditions. The biopsy helps doctors understand the health of the cervix and make decisions about treatment if needed. It is usually performed after an abnormal Pap smear or during a colposcopy exam. In this article, we will explore the concept of cervical biopsy, its importance in diagnosing cervical abnormalities, and the procedure involved.

Why might a woman need a colposcopy?

A woman may need a colposcopy for several reasons:

  • Abnormal Pap smear: If a Pap test shows unusual or abnormal cells, a colposcopy helps examine the cervix more closely.
  • HPV infection: Women diagnosed with the human papillomavirus (HPV), especially high-risk strains, may need this test to check for cell changes.
  • Unexplained bleeding: To investigate abnormal vaginal bleeding, especially after sex or between periods.

 

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About Cervical Biopsy

A cervical biopsy is a procedure in which a small sample of cervical tissue is obtained for laboratory analysis. The cervix, located at the lower end of the uterus, plays a vital role in reproductive health. Abnormalities in cervical cells, often caused by human papillomavirus (HPV) infection, can lead to precancerous or cancerous changes.

Types of cervical biopsies

There are different types of cervical biopsies, depending on how much tissue needs to be examined:

  1. Punch biopsy: A small tool is used to take a tiny piece of tissue from the cervix. This is the most common type of cervical biopsy and is typically done in a doctor's office. It causes minimal discomfort.

  2. Cone biopsy: A larger, cone-shaped portion of the cervix is removed for testing. This is done under anesthesia and is used when more tissue is needed, especially if previous tests showed abnormal cells.

  3. Endocervical curettage (ECC): This procedure scrapes the lining of the cervical canal to collect tissue. It's done when abnormal cells are found deeper inside the cervix.

Risk & Complications of Cervical biopsies

Cervical biopsies, while generally safe, do carry some risks and possible side effects. These vary depending on the type of biopsy performed and the individual’s overall health. Here's a detailed look at the risks:

1. Bleeding:

  • Punch Biopsy: Minor bleeding is common after this procedure, usually lasting a few days.
  • Cone Biopsy: This involves removing a larger tissue sample, so heavier bleeding may occur. In some cases, a patient may experience prolonged bleeding, requiring medical attention.

2. Infection: There’s a small risk of infection following any cervical biopsy. Signs include fever, foul-smelling discharge, or severe abdominal pain. Infections can be treated with antibiotics.

3. Pain or Discomfort: Mild cramping or discomfort is common after a cervical biopsy, especially with a punch biopsy. For cone biopsies, cramping may last longer due to the more invasive nature of the procedure.

4. Scarring: After a cone biopsy, there is a small risk of scarring on the cervix. This is known as cervical stenosis, which can cause complications like difficulty getting pregnant or problems during labor.

5. Premature Birth Risk: In rare cases, having a cone biopsy can increase the risk of premature birth in future pregnancies due to the weakening of the cervix.

6. Fainting: Some patients experience lightheadedness or fainting during or after the procedure, especially if they’re sensitive to pain or anxious about the procedure.

Post-Procedure Care:

  • After the biopsy, patients are advised to avoid strenuous activities, sexual intercourse, and tampon use for a few days to reduce the risk of complications.
  • It's also important to follow up with the doctor for results and further treatment if any abnormal cells are detected.

Who performs a colposcopy?

A colposcopy is performed by a healthcare professional known as a gynecologist. Gynecologists specialize in women's reproductive health and are trained to perform this procedure. Sometimes, an experienced nurse practitioner or a doctor with training in women’s health may also conduct a colposcopy. The procedure is typically recommended after an abnormal Pap test result, to examine the cervix, vagina, and vulva more closely for signs of disease. During the procedure, the healthcare provider uses a special magnifying instrument called a colposcope to get a detailed view of the tissue and detect abnormalities.

What happens after the colposcopy?

After a colposcopy, most women can return to normal activities right away. If a biopsy was taken, you may experience some light spotting or mild cramping for a few days. It's common to have a dark discharge from the vagina due to the solution applied to stop bleeding during the procedure. Avoid using tampons, douching, or having sexual intercourse for a week or until any discharge or bleeding stops to allow healing.

Your doctor will inform you when to expect the biopsy results, usually within 1 to 2 weeks. If the results show abnormal cells, your doctor will discuss further steps, which could include treatment or follow-up tests. In most cases, if no biopsy was taken, no further care is needed beyond regular check-ups. If you experience heavy bleeding, severe pain, or signs of infection like fever, contact your healthcare provider immediately.

How To Prepare For A Cervical Biopsy

A few specific procedures prepare a person for a cervical biopsy, allowing it to proceed smoothly.

  • Avoid tampons, vaginal creams, medications, or douches should be used for a minimum of 24 hours before the procedure. 

  • Sexual intercourse should be avoided for at least 24 hours prior. 

  • Tell your doctor if there is a possibility you are pregnant. 

  • Inform the doctor about any allergies, especially to medications, latex, or anesthetics.

  • Make sure to tell the doctor about any medications you are taking, including over-the-counter drugs and herbal supplements.

  • Tell your doctor if you have any bleeding disorders or are on blood-thinning medicines. 

  • Your doctor may tell you to take a pain reliever before the procedure. Make sure to discuss it with them. 

  • The procedure should be scheduled for a day other than the one on which the menstrual period begins so that the bleeding from the period does not interfere with the procedure. 

  • Typically, a woman is advised to empty her bladder before the procedure.

Benefits Of Cervical Biopsy

The major benefit of a cervical biopsy is its ability to definitively diagnose cervical abnormalities, including precancerous/cancerous conditions. This allows for the early detection of cancer and for timely intervention in cases of dysplasia. 

In many respects, a biopsy is similar to a Pap smear but allows for the actual sampling of tissue for precise identification. This is also applicable in the case of genital warts, cervical polyps, and effects of DES exposure. The biopsy results will assist in deciding the most suitable treatment. Thus, it promotes peace of mind by looking for early detection and treatment for possibly harmful cell changes.

Procedure of Cervical Biopsy

The procedure for cervical biopsy typically involves the following steps:

  1. Preparation: Before the procedure, the patient may be instructed to empty their bladder. It is essential to inform the healthcare provider about any allergies or medications being taken.

  2. Positioning: The patient is positioned on a gynecological exam table, similar to a pelvic exam. The feet are placed in stirrups, allowing the healthcare provider clear access to the cervix.

  3. Speculum Insertion: A speculum is gently inserted into the vagina to visualize and access the cervix. This may cause a sensation of pressure but should not be overly painful.

  4. Local Anesthesia (optional): Depending on the healthcare provider's preference and the patient's comfort, a local anesthetic may be applied to the cervix to numb the area. This is typically done using a numbing spray or injection.

  5. Tissue Sample Collection: Different techniques may be used to obtain a tissue sample from the cervix:
    a. Punch Biopsy: A small instrument called a biopsy punch or forceps is used to remove a small piece of cervical tissue. This may cause a brief pinch or cramp-like sensation.
    b. Endocervical Curettage (ECC): A narrow instrument called a curette is gently inserted into the cervical canal to scrape and collect cells from the endocervical area.

  6. Hemostasis and Care: After the tissue sample is obtained, any bleeding is usually controlled using a specialized solution or a small electric probe. The speculum is then removed, and the patient is provided with instructions for post-biopsy care.

  7. Laboratory Analysis: The tissue sample is sent to a laboratory for microscopic examination by a pathologist. The results are typically available within a few days to a week.

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